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Fatty acid oxidation inhibitors
・ Fatty acid synthase
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Fatty acid oxidation inhibitors : ウィキペディア英語版
Fatty acid oxidation inhibitors
Fatty acid oxidation inhibitors are a new potent class of drugs used in treatment of stable angina pectoris and an addition in treatment of chronic heart failure.
==Drugs==

* CPT-I inhibitors: Etomoxir, Oxfenicine, Perhexiline
CPT-I (carnitine palmitoyl transferase) converts fatty acyl-CoA to fatty acyl-carnitine.
* Carnitine biosynthesis inhibitor: Mildronate〔J Cardiovasc Pharmacol. 2006 Dec;48(6):314-9.; Mildronate, an inhibitor of carnitine biosynthesis, induces an increase in gamma-butyrobetaine contents and cardioprotection in isolated rat heart infarction. ; Liepinsh E, Vilskersts R, Loca D, Kirjanova O, Pugovichs O, Kalvinsh I, Dambrova M.;Latvian Institute of Organic Synthesis, Riga, Latvia.http://www.ncbi.nlm.nih.gov/pubmed/17204911〕
* 3-KAT inhibitors: Trimetazidine
3-KAT (3-ketoacyl-coenzyme A thiolase) inhibitors directly inhibits fatty acid beta-oxidation.
* pFOX (partial fatty acid oxidation inhibitors): Ranolazine
pFOX directly inhibits fatty acid beta-oxidation.〔Partial fatty acid oxidation inhibitors: a potentially new class of drugs for heart failure; European Journal of Heart Failure 4 2002. 3-6; http://eurjhf.oxfordjournals.org/content/4/1/3.full.pdf+html〕

抄文引用元・出典: フリー百科事典『 ウィキペディア(Wikipedia)
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